For this post I will be using this Django project:

git clone https://github.com/38130/mysite

Installation 

pip install cython

 Generate the Compiled Code

from setuptools import setup, Extension
from Cython.Build import cythonize

exts = [
    Extension("mysite.mysite.settings", ["mysite/mysite/settings.py"]),
    Extension("mysite.mysite.urls", ["mysite/mysite/urls.py"]),
    Extension("mysite.mysite.asgi", ["mysite/mysite/asgi.py"]),
    Extension("mysite.mysite.wsgi", ["mysite/mysite/wsgi.py"]),
    Extension("mysite.polls.models", ["mysite/polls/models.py"]),
    Extension("mysite.polls.views", ["mysite/polls/views.py"]),
    Extension("mysite.polls.admin", ["mysite/polls/admin.py"]),
    Extension("mysite.polls.urls", ["mysite/polls/urls.py"]),
    Extension("mysite.polls.apps", ["mysite/polls/apps.py"]),

]
setup(
    ext_modules=cythonize(
        exts,
        build_dir="build_cython",
    ),
)

python setup.py build_ext --inplace

May require updated Visual Studio Build Tools https://visualstudio.microsoft.com/visual-cpp-build-tools/

• Desktop development with C++
• MSVC v14.x C++ build tools
• Windows 10 SDK (or 11 SDK)

You can now remove all the .py files:

• mysite/mysite/settings.py
• mysite/mysite/urls.py
• mysite/mysite/asgi.py
• mysite/mysite/wsgi.py
• mysite/polls/models.py
• mysite/polls/views.py
• mysite/polls/admin.py
• mysite/polls/urls.py
• mysite/polls/apps.py

python manage.py runserver